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Clinical trial designs for prospective validation of biomarkers. HT1-associated liver and kidney failure can be prevented by blocking an enzyme upstream of FAH in the tyrosine breakdown pathway with 2-(2-nitro-4-trifluoromethylbenzoyl)-1,3-cyclohexanedione (NTBC). For this purpose, 46 PD patients what is sildenafil used for were randomly and equally divided into groups A and B.

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